Vipre and ESET are my personal choices for Business.Avast! Email Server Security ensures real-time protection of corporate data, safeguarding servers against viruses and other threats that might be transmitted via e-mail. It has been proven that is breaks more than it fixes. Yes, stay away from anything that Symantec makes. They are also not free for commercial use, have to buy licenses for them. They don't do the same thing that ESET, Vipre, Sophos, and other do. Malwarebytes and SuperAntiSpyware are not AV programs, they are AntiMalware.

It can only be used on desktops that are in 10 computers or less work environment. I know a lot of people and companies do it since it is easy to install to 1 software on everything, but your servers are gold and if that same virus hits your server, you have some long nights ahead of you. If you get a virus on a desktop and it start spreading and the AV stands by and does nothing, then your server is likely to get hit too. MalwareBytes, SuperAntiSpyware, and CCleaner to name a few. Just have a toolkit handy to root out the little buggers when they do show up (and they will). And in some cases, it can happen just going to normal web sites that they visit every day. Your users will eventually find a way to infect your computers, regardless of the software you are using. One thing to take note of, no AV software is fullproof. MSE is updated regularly, depending on your Windows/Microsoft Updates settings, and has the benefit of being built by the same company that makes the OS (one would think this to be an advantage, but.). Surprisingly, Microsoft seems to have put together a good bit of software. I can say that I have used Trend (enterprise and standalone), Norton, McAfee, AVG, and Microsoft Security Essentials (MSE), and have nothing bad to say about MSE. I have a hard time justifying 'free' AV software in a domain environment, but I am sure someone out there can make this argument if you are interested. There are also free versions with real time scan: Avast, AVG, and truthfully, Microsoft Security Essentials. You can use paid versions of McAfee, MalwareBytes, Trend Micro, Sophos, and a few others.

I know there will be some who disagree, but stay away from Symantec/Norton (my opinion). Now, if this is a standalone, not part of a domain, then your options are numerous. If you are running individual licensing on your AV, then I'd still try to stick with what is being used by the rest of the network, assuming this is still in a domain environment. If this is a domain environment, I'd recommend using the same AV software as the rest of the network.

Avast for windows server 2008 r2 64 bit